DNA Origami Meets Polymers: A Powerful Tool for the Design of Defined Nanostructures. Issue 12 (28th October 2020)

• Record Type: Journal Article
• Authors: Hannewald, Nadine; Winterwerber, Pia; Zechel, Stefan; Ng, David Y. W.; Hager, Martin D.; Weil, Tanja; Schubert, Ulrich S.
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 12(2021)
• Page Start: 6218
• Page End: 6229
• Publication Date: 2020-10-28
• Subjects: DNA origami -- hybrid materials -- nanostructures -- polymer chemistry -- surface modification; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202005907
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The combination of DNA origami nanostructures and polymers provides a new possibility to access defined structures in the 100 nm range. In general, DNA origami serves as a versatile template for the highly specific arrangement of polymer chains. Polymer‐DNA hybrid nanostructures can either be created by growing the polymer from the DNA template or by attaching preformed polymers to the DNA scaffold. These conjugations can be of a covalent nature or be based on base‐pair hybridization between respectively modified polymers and DNA origami. Furthermore, the negatively charged DNA backbone permits interaction with positively charged polyelectrolytes to form stable complexes. The combination of polymers with tuneable characteristics and DNA origami allows the creation of a new class of hybrid materials, which could offer exciting applications for controlled energy transfer, nanoscale organic circuits, or the templated synthesis of nanopatterned polymeric structures. Abstract : The combination of DNA origami with synthetic polymers results in a new class of materials with interesting properties and characteristics. This approach is more precise than conventional nanofabrication methods, such as the positioning of single polymer strands. This Minireview shows the potential preparation of nanostructures from polymers and two‐ or three‐dimensional DNA origami.