Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products. (3rd September 2020)

• Record Type: Journal Article
• Authors: Liu, Yiman; Yang, Shenshen; Wang, Kailong; Lu, Jia; Bao, Xiaomei; Wang, Rui; Qiu, Yuling; Wang, Tao; Yu, Haiyang
• Is Part Of: Cell proliferation. Volume 53:Number 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-03
• Subjects: active ingredients -- cell senescence -- Traditional Chinese Medicine -- tumour; Cell proliferation -- Periodicals; 571.84
• DOI: 10.1111/cpr.12894
• Languages: English
• ISSNs: 0960-7722

Abstract

Abstract: Cancer is the principal cause of death and a dominant public health problem which seriously threatening human life. Among various ways to treat cancer, traditional Chinese medicine (TCM) and natural products have outstanding anti‐cancer effects with their unique advantages of high efficiency and minimal side effects. Cell senescence is a physiological process of cell growth stagnation triggered by stress, which is an important line of defence against tumour development. In recent years, active ingredients of TCM and natural products, as an interesting research hotspot, can induce cell senescence to suppress the occurrence and development of tumours, by inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogenes. In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti‐cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro‐senescent cancer. Abstract : As an important anti‐tumour function, cell senescence could prevent the cellular replication of damaged DNA. Cell senescence is usually stimulated by damages, such as telomere shortening, DNA damage and oncogene‐induced senescence. Active ingredients of TCM and natural products, can induce cell senescence to suppress the occurrence and development of tumours, through inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogene.