Resource allocation in metabolic networks: kinetic optimization and approximations by FBA. (27th November 2015)

• Record Type: Journal Article
• Authors: Müller, Stefan; Regensburger, Georg; Steuer, Ralf
• Is Part Of: Biochemical Society transactions. Volume 43:Number 6(2015)
• Page Start: 1195
• Page End: 1200
• Publication Date: 2015-11-27
• Subjects: elementary flux modes -- enzyme kinetics -- metabolic optimization -- non-linear optimization -- satFBA; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20150156
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Based on recent theoretical results on optimal flux distributions in kinetic metabolic networks, we explore the congruences and differences between solutions of kinetic optimization problems and results obtained by constraint-based methods. We demonstrate that, for a certain resource allocation problem, kinetic optimization and standard flux balance analysis (FBA) give rise to qualitatively different results. Furthermore, we introduce a variant of FBA, called satFBA, whose predictions are in qualitative agreement with kinetic optimization.