Differential targeting of cPKC and nPKC decodes and regulates Ca2+ and lipid signalling. (17th November 2014)

• Record Type: Journal Article
• Authors: Hui, Xin; Kaestner, Lars; Lipp, Peter
• Is Part Of: Biochemical Society transactions. Volume 42:Number 6(2014)
• Page Start: 1538
• Page End: 1542
• Publication Date: 2014-11-17
• Subjects: calcium signalling -- confocal microscopy -- fluorescent protein -- fluorescence resonance energy transfer sensor (FRET sensor) -- lipid signalling -- signal transduction; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20140239
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Protein kinases C (PKCs) are ubiquitously expressed and play critical roles in a plethora of physiological and pathophysiological processes. Owing to PKCs' highly conserved phosphorylation consensus sequence, it has been difficult to distinguish the role of individual PKC isoforms. Recently, the identification of novel membrane targeting via subcellularly targeted diacylglycerol production found for novel PKCs (nPKCs), together with a characterization of their putative functions, has shed new light on the specific roles of individual PKCs in cellular processes.