Recent advances in target identification of bioactive natural products. Issue 1 (2nd January 2019)

• Record Type: Journal Article
• Authors: Yoshida, Minoru
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 1(2019)
• Page Start: 1
• Page End: 9
• Publication Date: 2019-01-02
• Subjects: Chemical genetics -- yeast genetics -- mode of action -- target molecule -- profiling; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2018.1533804
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Natural products are a tremendous source of tool discovery for basic science and drug discovery for clinical uses. In contrast to the large number of compounds isolated from nature, however, the number of compounds whose target molecules have been identified so far is fairly limited. Elucidation of the mechanism of how bioactive small molecules act in cells to induce biological activity (mode of action) is an attractive but challenging field of basic biology. At the same time, this is the major bottleneck for drug development of compounds identified in cell-based and phenotype-based screening. Although researchers' experience and inspiration have been crucial for successful target identification, recent advancements in genomics, proteomics, and chemical genomics have made this challenging task possible in a systematic fashion. Graphical abstract: : A general scheme for target identification of small molecules.