A novel Ca2+-signal transduction inhibitor, kujigamberol C, isolated from Kuji amber. Issue 9 (2nd September 2019)

• Record Type: Journal Article
• Authors: Takahashi, Honoka; Koshino, Hiroyuki; Maruyama, Miku; Shinden, Hisao; Kimura, Ken-ichi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 9(2019)
• Page Start: 1630
• Page End: 1634
• Publication Date: 2019-09-02
• Subjects: Kuji amber -- Saccharomyces cerevisiae -- 15-nor-8-labden-13-ol -- kujigamberol C; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2019.1611410
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: A novel labdane type diterpenoid, 15-nor-8-labden-13-ol, named kujigamberol C, was isolated from Kuji amber using a modified isolation method to increase the yield of biologically active compounds. The structure was determined using HREIMS, 1D and 2D NMR. Kujigamberol C showed growth-restoring activity against mutant yeast via Ca 2+ -signal transduction. Graphical abstract: : A novel Ca 2+ -signal transduction inhibitor, kujigamberol C, was isolated from Kuji amber. It showed the growth-restoring activity against the mutant yeast.