Lactosucrose attenuates intestinal inflammation by promoting Th2 cytokine production and enhancing CD86 expression in colitic rats. Issue 4 (3rd April 2015)

• Record Type: Journal Article
• Authors: Zhou, Yan; Ruan, Zheng; Zhou, Xiaoli; Huang, Xiaoliu; Li, Hua; Wang, Ling; Zhang, Cui; Deng, Zeyuan; Wu, Guoyao; Yin, Yulong
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 4(2015)
• Page Start: 643
• Page End: 651
• Publication Date: 2015-04-03
• Subjects: lactosucrose -- inflammation bowel disease -- dendritic cell -- Th1 and Th2 balance; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.991680
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Some oligosaccharides have immunoregulatory and anti-inflammatory functions in the intestine. This study investigated the immunoregulatory effect of lactosucrose (LS) on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitic rats. Alkaline phosphatase activity was increased but myeloperoxidase activity was decreased in the LS-TNBS group, as compared with the TNBS group (colitis rats without receiving LS). LS supplementation stimulated IL-4 and IL-10 production, while up-regulating CD86 expression in dendritic cells. LS supplementation reduced the ratio of CD80/CD86 and the ratio of IFN-γ/IL-4 compared to the TNBS group. Moreover, IFN-γ was significantly correlated with CD80 ( r = 0.764, p < 0.01), whereas IL-4 was significantly correlated with CD86 ( r = 0.489, p < 0.05). These results indicated that LS attenuated colitis by promoting the production of Th2-type cytokines and rebalancing the ratio of Th1/Th2 and that enhanced IL-4 production is correlated with enhanced CD86 expression in the gut. Therefore, LS is a functional food for patients with inflammatory bowel disease. Abstract: : LS attenuated TNBS-induced colitis by promoting the production of Th2-type cytokines and rebalancing the ratio of Th1/Th2. And the enhanced IL-4 production is correlated with enhanced CD86 expression.