Contributions of tryptophan 2, 3-dioxygenase and indoleamine 2, 3-dioxygenase to the conversion of d-tryptophan to nicotinamide analyzed by using tryptophan 2, 3-dioxygenase-knockout mice. Issue 5 (4th May 2014)

• Record Type: Journal Article
• Authors: Maeta, Akihiro; Sano, Mitsue; Fukuwatari, Tsutomu; Funakoshi, Hiroshi; Nakamura, Toshikazu; Shibata, Katsumi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 5(2014)
• Page Start: 878
• Page End: 881
• Publication Date: 2014-05-04
• Subjects: d-tryptophan -- biosynthesis -- tryptophan 2, 3-dioxygenase -- indoleamine 2, 3-dioxygenase -- nicotinamide; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.905185
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: We investigated the contribution percentage of tryptophan 2, 3-dioxygenase (TDO) and indoleamine 2, 3-dioxygenase (IDO) to the conversion of d -tryptophan to nicotinamide in TDO-knockout mice. The calculated percentage conversions indicated that TDO and IDO oxidized 70 and 30%, respectively, of the dietary l -tryptophan. These results indicate that both TDO and IDO biosynthesize nicotinamide from d -tryptophan and l -tryptophan in mice.