Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice. Issue 1 (2nd January 2015)

• Record Type: Journal Article
• Authors: Park, Hyeon Soo; Hwang, Yong Hyeon; Kim, Mun Ki; Hong, Gyeong Eun; Lee, Ho Jeong; Nagappan, Arulkumar; Yumnam, Silvia; Kim, Eun Hee; Heo, Jeong Doo; Lee, Sang Joon; Won, Chung Kil; Kim, Gon Sup
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 1(2015)
• Page Start: 147
• Page End: 154
• Publication Date: 2015-01-02
• Subjects: Grifola frondosa -- polysaccharides -- atopic dermatitis -- Nc/Nga mice -- interleukins; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.963500
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body. To extend the application of GF polysaccharides (GFP) for atopic dermatitis (AD), we investigated the effects of GFP on the 2, 4-dinitrochlorobenzene-induced AD-like skin lesion in NC/Nga mice. GFP treatment significantly reduced the dorsa skin dermatitis score and combination treatment with GFP, and dexamethasone has a synergistic effect in AD-like skin lesion by reduced Serum IgE, mast cells infiltration, and cytokines expression. These results indicate that GFP suppressed the AD-like skin lesions by controlling the Th-1/Th-2-type cytokines in NC/Nga mice. These findings strongly suggest that GFP can be useful for AD patients as a novel therapeutic agent and might be used for corticosteroids replacement or supplement agent. Graphical abstract: : This study suggests that GFP modulates the Th-1/Th-2 response and mast cell infiltration is a major mechanism of the AD like skin lesion in NC/Nga mice.