Thiol modification by bioactivated polyphenols and its potential role in skin inflammation. Issue 6 (3rd June 2014)

• Record Type: Journal Article
• Authors: Nakamura, Yoshimasa; Ishii, Takeshi; Abe, Naomi; Murata, Yoshiyuki
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 6(2014)
• Page Start: 1067
• Page End: 1070
• Publication Date: 2014-06-03
• Subjects: polyphenol -- tyrosinase -- glutathione -- protein thiols -- skin inflammation; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.905190
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: In the present study, we evaluated the modifying behavior of simple phenolic compounds on the sulfhydryl groups of glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither the monophenols nor O -methylated catechol, can modify the sulfhydryl groups in a phenol oxidase-dependent manner. The possible involvement of polyphenol bioactivation in the enhancement of skin inflammation was also suggested.