Synthetic approach toward complexity of sialic acid-containing glycans. Issue 3 (4th March 2015)

• Record Type: Journal Article
• Authors: Ando, Hiromune
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 3(2015)
• Page Start: 343
• Page End: 346
• Publication Date: 2015-03-04
• Subjects: sialic acid -- glycan -- glycosylation -- organic synthesis; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.990228
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: The biological relevance of sialic acid-containing glycans (sialo-glycans) to various interactions at the cell surface has increased the demand for the supply of structurally defined sialo-glycans. Due to their unique structures, the stereoselective synthesis of glycosides of sialic acid is inherently difficult, which makes the synthetic approach to synthesize diverse and complex sialo-glycans far from successful. However, the gap between the chemical and natural synthesis of complex sialo-glycans is narrowing through the emergence of synthetic methods. This review highlights recent progress made in the synthesis of complex sialo-glycans via cutting-edge synthetic methods. Graphical abstract: : The development of versatile synthetic units of sialic acid allowed to synthesize highly complicated sialic acid-containing molecules.