The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice. Issue 10 (3rd October 2014)

• Record Type: Journal Article
• Authors: Liu, Lei; Zhang, Mingwei; Zhang, Ruifen; Lee, Mira; Wang, Zhen; Hou, Jingang; Sung, Chang-Keun
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 10(2014)
• Page Start: 1710
• Page End: 1715
• Publication Date: 2014-10-03
• Subjects: Chong-Myung-Tang -- cell survival -- cell proliferation -- dentate gyrus -- spatial memory; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.930319
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement. Graphical abstract: : The multi-herbal formula Chong-Myung-Tang increases cell survival but not cell proliferation in the dentate gyrus of aged mice.