Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells. Issue 11 (2nd November 2014)

• Record Type: Journal Article
• Authors: Horiba, Taro; Katsukawa, Masahiro; Abe, Keiko; Nakai, Yuji
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 11(2014)
• Page Start: 1923
• Page End: 1929
• Publication Date: 2014-11-02
• Subjects: alpha-mangostin -- DNA microarray -- myoblast -- myotube -- xanthone; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.940832
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived C2C12 myoblasts. α-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in α-mangostin-treated cells. These results indicate that α-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts. Graphical abstract: : Alpha-mangostin promotes myoblast differentiation by stimulating expression of genes related to myotube formation.