Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate. Issue 3 (4th March 2014)

• Record Type: Journal Article
• Authors: Mathiyalagan, Ramya; Subramaniyam, Sathiyamoorthy; Kim, Yeon Ju; Natarajan, Sathishkumar; Min, Jin Woo; Kim, Se Young; Yang, Deok Chun
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 3(2014)
• Page Start: 466
• Page End: 468
• Publication Date: 2014-03-04
• Subjects: Panax ginseng -- compound k -- polyethylene glycol -- solubility -- cancer; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.885827
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.