Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells. Issue 1 (2nd January 2015)

• Record Type: Journal Article
• Authors: Tang, Yue; Abe, Naomi; Yoshimoto, Motoko; Zhu, Beiwei; Murata, Yoshiyuki; Nakamura, Yoshimasa
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 1(2015)
• Page Start: 159
• Page End: 163
• Publication Date: 2015-01-02
• Subjects: benzyl isothiocyanate -- interleukin-13(IL-13) -- mitogen-activated protein kinase (MAPK) -- nuclear factor-κB (NF-κB) -- nuclear factor of activated T cells c1(NFATc1); Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.963503
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium ionophore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogen-activated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.