Bactericidal activity of nukacin ISK-1: an alternative mode of action. Issue 7 (3rd July 2014)

• Record Type: Journal Article
• Authors: Roy, Urmi; Islam, Mohammad Riazul; Nagao, Jun-ichi; Iida, Hiroshi; Mahin, Abdullah-Al; Li, Mengqi; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 7(2014)
• Page Start: 1270
• Page End: 1273
• Publication Date: 2014-07-03
• Subjects: lantibiotic -- antimicrobial peptide -- mode of action -- unusual amino acid -- bactericidal activity; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.918485
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: We previously reported bacteriostatic action of nukacin ISK-1 against Bacillus subtilis JCM 1465 T . Here, we found its bactericidal activity against Micrococcus luteus DSM 1790 and Staphylococcus simulans 22, showing decrease in cell viability, cell lysis, and dissipation of the membrane potential. Moreover, leakage of small molecules such as K +, suggested the formation of small-sized or specific K + -conducting-pores by nukacin ISK-1.