Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice. Issue 9 (2nd September 2019)

• Record Type: Journal Article
• Authors: Sato, Mizuho; Okuno, Alato; Suzuki, Kazunori; Ohsawa, Natsuki; Inoue, Eiichi; Miyaguchi, Yuji; Toyoda, Atsushi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 9(2019)
• Page Start: 1756
• Page End: 1765
• Publication Date: 2019-09-02
• Subjects: Depression -- hesperidin -- social defeat -- kynurenine -- mouse; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2019.1621152
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Depressive disorders are partly caused by chronic inflammation through the kynurenine (KYN) pathway. Preventive intervention using anti-inflammatory reagents may be beneficial for alleviating the risk of depression. In this study, we focused on the Japanese local citrus plant, Citrus tumida hort. ex Tanaka ( C. tumida ; CT), which contains flavonoids such as hesperidin that have anti-inflammatory actions. The dietary intake of 5% immature peels of CT fruits slightly increased stress resilience in a subchronic and mild social defeat (sCSDS) model in mice. Moreover, the dietary intake of 0.1% hesperidin significantly increased stress resilience and suppressed KYN levels in the hippocampus and prefrontal cortex in these mice. In addition, KYN levels in the hippocampus and prefrontal cortex were significantly correlated with the susceptibility to stress. In conclusion, these results suggest that dietary hesperidin increases stress resilience by suppressing the augmentation of KYN signaling under sCSDS. Graphical abstract: : Dietary intake of hesperidin increased stress resilience in the subchronic and social defeat stress model of mice.