Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε). Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Yamauchi, Yoko; Kimoto, Hikari; Yang, Xianyu; Filkin, Sergey; Utkin, Yuri; Kubo, Tai; Inagaki, Hidetoshi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 80:Issue 1(2016)
• Page Start: 158
• Page End: 161
• Publication Date: 2016-01-02
• Subjects: Papuan pigmy mulga snake -- venom gland -- three-finger toxin -- nAChR; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2015.1065169
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Three-finger toxins (3FTxs) are one of the major components in snake venoms. In this study, we isolated a cDNA encoding a short-chain 3FTx, Pr -SNTX, from Pseudechis rossignolii . The amino acid sequence of Pr -SNTX is nearly identical to that of its ortholog in Pseudechis australis . Pr -SNTX protein inhibited muscle-type (α2 βδε), but not neuronal α7 nicotinic acetylcholine receptor (nAChR) activity.