Identification of molecular target of diallyl trisulfide in leukemic cells. Issue 8 (3rd August 2014)

• Record Type: Journal Article
• Authors: Suda, Shun; Watanabe, Kazunari; Tanaka, Yuki; Watanabe, Kazuhiro; Tanaka, Rie; Ogihara, Jun; Ariga, Toyohiko; Hosono-Fukao, Tomomi; Hosono, Takashi; Seki, Taiichiro
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 8(2014)
• Page Start: 1415
• Page End: 1417
• Publication Date: 2014-08-03
• Subjects: garlic -- heat shock protein 27 (HSP27) -- diagonal gel electrophoresis -- U937 -- diallyl trisulfide; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.921563
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27). Hsp27 is suggested to be one of the molecular target of DATS in U937.