SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae. Issue 8 (3rd August 2019)

• Record Type: Journal Article
• Authors: Masumura, Koji; Matsukami, Sachi; Yonekita, Kumiko; Kanai, Muneyoshi; Kume, Kazunori; Hirata, Dai; Mizunuma, Masaki
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 8(2019)
• Page Start: 1473
• Page End: 1476
• Publication Date: 2019-08-03
• Subjects: Saccharomyces cerevisiae -- Sko1 -- lifespan -- osmotic stress -- oxidative stress; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2019.1571901
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Sko1 plays a key role in the control of gene expression by osmotic and oxidative stress in yeast. We demonstrate that the decrease in chronological lifespan (CLS) of hog1 Δ cells was suppressed by SKO1 deletion. sko1 Δ single mutant cells were shown to have a longer CLS, thus implicating Sko1 in the regulation of their CLS.