Chemical constituents of Brazilian Propolis from the state of Bahia and their growth inhibitory activities against cancer cells. Issue 3 (4th March 2018)

• Record Type: Journal Article
• Authors: Mitsui, Taichi; Hotta, Sho; Tazawa, Shigemi; Arai, Yasuko; Kato, Kenji; Ichihara, Kenji
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 82:Issue 3(2018)
• Page Start: 417
• Page End: 421
• Publication Date: 2018-03-04
• Subjects: Brazilian propolis -- Bahia state -- 2-Phenoxychromone -- anti-cancer; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2018.1427550
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: A novel 2-phenoxychromone (1) and five known flavones (2-6) were isolated from northeastern Brazilian propolis in the state of Bahia. The chemical structures of these six compounds were determined by spectroscopic investigations and single-crystal X-ray analysis. The isolated compounds showed growth-inhibitory activities, in varying degrees, against human tumor cell lines. This is the first report on the discovery of a novel 2-phenoxychromone from propolis. Abstract: : A novel 2-phenoxychromone (1 ) and five known flavones (2–6 ) were isolated from Brazilian propolis in the state of Bahia.