Ubr1p-Cup9p-Ptr2p pathway involves in the sensitivity to readthrough compounds negamycin derivatives in budding yeast. Issue 10 (3rd October 2019)

• Record Type: Journal Article
• Authors: Hamada, Keisuke; Naito, Akari; Hamaguchi, Yu; Kanesaki, Yu; Kasahara, Koji; Taguchi, Akihiro; Omura, Noriko; Hayashi, Yoshio; Usui, Takeo
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 10(2019)
• Page Start: 1889
• Page End: 1892
• Publication Date: 2019-10-03
• Subjects: Dipeptide transporter -- negamycin -- readthrough -- Ubr1p-Cup9p-Ptr2p pathway; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2019.1625263
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: In this study, we found that dipeptide transporter Ptr2p is the putative transporter of read-through compounds (+)-negamycin derivatives TCP-126 and TCP-112, in budding yeast. Ptr2p expression and activity were correlated with the TCP-112 sensitivity, and dipeptide with high affinity to Ptr2p suppressed the TCP-112 activity. These results suggest that dipeptide transporter is one of the determinants of negamycin analogs sensitivity. Abbreviation : PTC: premature termination codon.