Insights into the post-transcriptional regulation of the mitochondrial electron transport chain. (15th October 2016)

• Record Type: Journal Article
• Authors: Sirey, Tamara M.; Ponting, Chris P.
• Is Part Of: Biochemical Society transactions. Volume 44:Number 5(2016)
• Page Start: 1491
• Page End: 1498
• Publication Date: 2016-10-15
• Subjects: eukaryotic gene expression -- metabolic regulation -- microRNA -- mitochondrial respiration -- RNA-binding proteins; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20160100
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The regulation of the mitochondrial electron transport chain is central to the control of cellular homeostasis. There are significant gaps in our understanding of how the expression of the mitochondrial and nuclear genome-encoded components of the electron transport chain are co-ordinated, and how the assembly of the protein complexes that constitute the electron transport chain are regulated. Furthermore, the role post-transcriptional gene regulation may play in modulating these processes needs to be clarified. This review summarizes the current knowledge regarding the post-transcriptional gene regulation of the electron transport chain and highlights how noncoding RNAs may contribute significantly both to complex electron transport chain regulatory networks and to mitochondrial dysfunction.