Echinacea purpurea water extracts suppress the release of chemical mediators from mast cells. Issue 4 (6th January 2021)

• Record Type: Journal Article
• Authors: Zorig, Anuu; Toko, Rine; Sukhbold, Enkhtsetseg; Takasugi, Mikako; Arai, Hirofumi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 85:Issue 4(2021)
• Page Start: 931
• Page End: 940
• Publication Date: 2021-01-06
• Subjects: allergy -- Echinacea purpurea -- histamine -- leukotriene -- mast cell; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1093/bbb/zbaa125
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Histamine and leukotrienes (LTs), the chemical mediators released from mast cells, play an important role in type-I allergies such as hay fever. Echinacea purpurea (EP) has traditionally been used for herbal tea and has been reported to show biological functions. We evaluated the inhibitory activity of water extracts of EP petals, leaves, and stems against the chemical mediators released from mast cell lines. Petal and leaf extracts exhibited a significant inhibitory effect on histamine release from the stimulated cells, while the stem extract did not exert any effect. Activity of the petal extract was much stronger than that of the leaf extract. All the extracts significantly suppressed LTB4 production in the stimulated cells and displayed similar activities. The petal extract decreased Syk phosphorylation and Ca 2+ influx associated with signal transduction in the stimulated cells. These results suggest that EP petal extract may have a relieving effect on allergic symptoms. Graphical Abstract: