Incidence, risk factors, and thrombotic load of pulmonary embolism in patients hospitalized for COVID-19 infection. Issue 2 (February 2021)

• Record Type: Journal Article
• Authors: García-Ortega, Alberto; Oscullo, Grace; Calvillo, Pilar; López-Reyes, Raquel; Méndez, Raúl; Gómez-Olivas, José Daniel; Bekki, Amina; Fonfría, Carles; Trilles-Olaso, Laura; Zaldívar, Enrique; Ferrando, Ana; Anguera, Gabriel; Briones-Gómez, Andrés; Reig-Mezquida, Juan Pablo; Feced, Laura; González-Jiménez, Paula; Reyes, Soledad; Muñoz-Núñez, Carlos F; Carreres, Ainhoa; Gil, Ricardo; Morata, Carmen; Toledo-Pons, Nuria; Martí-Bonmati, Luis; Menéndez, Rosario; Martínez-García, Miguel Ángel
• Is Part Of: Journal of infection. Volume 82:Issue 2(2021)
• Page Start: 261
• Page End: 269
• Publication Date: 2021-02
• Subjects: Pulmonary embolism -- COVID-19 -- Thrombosis -- Inflammation -- Computed tomography; ACE2 Angiotensin converting enzyme-2 -- Ao Aortic artery -- AUC-ROC Area under curve ROC -- BMI Body mass index -- CHOD CRP concentration + Heart rate + Oxygen saturation + D-dimer levels -- CI Confidence interval -- CRP C-reactive protein -- CTPA Computed tomography pulmonary angiography -- CXR chest X-ray -- HR Hazard Ratio -- ICU Intensive care units -- IL6 Interleukin-6 -- LDH Lactate dehydrogenase -- LV Left ventricle -- PA Pulmonary artery trunk -- PCR polymerase chain reaction -- PE Pulmonary embolism -- RR Respiratory rate -- RV Right ventricle -- SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 -- SD Standard deviation -- sPESI Simplified Pulmonary Embolism Severity Index -- spO2 Oxygen saturation -- VTE Venous thromboembolism; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2021.01.003
• Languages: English
• ISSNs: 0163-4453

Abstract

Summary: Objective: To determine the incidence, characteristics, and risk factors of pulmonary embolism (PE) among patients hospitalized for COVID-19. Patients and Methods: We performed a prospective observational study of a randomly selected cohort of consecutive patients hospitalized for COVID-19 infection between March 8, 2020 through April 25, 2020. All eligible patients underwent a computed tomography pulmonary angiography independently of their PE clinical suspicion and were pre-screened for a baseline elevated D-dimer level. Results: 119 patients were randomly selected from the 372 admitted to one tertiary hospital in Valencia (Spain) for COVID-19 infection during the period of study. Seventy-three patients fulfilled both the inclusion criteria and none of the exclusion criteria and were finally included in the study. Despite a high level of pharmacological thromboprophylaxis (89%), the incidence of PE was 35.6% (95% confidence interval [CI], 29.6 to 41.6%), mostly with a peripheral location and low thrombotic load (Qanadli score 18.5%). Multivariate analysis showed that heart rate (Hazard Ratio [HR], 1.04), room-air oxygen saturation (spO2) (HR, 0.87), D-dimer (HR, 1.02), and C-reactive protein (CRP) levels (HR, 1.01) at the time of admission were independent predictors of incident PE during hospitalization. A risk score was constructed with these four variables showing a high predictive value of incident PE (AUC-ROC: 0.86; 95% CI: 0.80 to 0.93). Conclusions: Our findings confirmed a high incidence of PE in hospitalized COVID-19 patients. Heart rate, spO2, D-dimer, and CRP levels at admission were associated with higher rates of PE during hospitalization.