Cover Picture: Furin‐Mediated Self‐Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors (Angew. Chem. Int. Ed. 8/2021). Issue 8 (1st February 2021)

• Record Type: Journal Article
• Authors: Yuan, Yue; Raj, Piyush; Zhang, Jia; Siddhanta, Soumik; Barman, Ishan; Bulte, Jeff W. M.
• Is Part Of: Angewandte Chemie international edition. Volume 60:Issue 8(2021)
• Page Start: 3825
• Page End: 3825
• Publication Date: 2021-02-01
• Subjects: furin -- nanoparticles -- olsalazine -- Raman spectroscopy -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202016964
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Single olsalazine molecules can be self‐assembled into nanoparticles by the tumor‐overexpressed enzyme furin following a 2‐cyanobenzothiazole (CBT)‐mediated biocompatible click condensation reaction and π–π stacking, as demonstrated by Ishan Barman, Jeff W. M. Bulte et al. in their Communication on page 3923 . These intracellular nanoparticles provide a differential Raman scattering signature, allowing highly specific imaging of cancer cells in vitro and in vivo.