Does pediatric heart transplant survival differ with various cardiac preservation solutions?. Issue 12 (22nd November 2020)

• Record Type: Journal Article
• Authors: Shaw, Taylor B.; Lirette, Seth; Carter, Kristen T.; Kutcher, Matthew E.; Baran, David A.; Copeland, Jack G.; Copeland, Hannah
• Is Part Of: Clinical transplantation. Volume 34:Issue 12(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-22
• Subjects: artificial organs -- dysfunction -- heart (allograft) function -- organ -- organ procurement -- perfusion -- preservation -- support devices: heart -- ventricular assist devices; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14122
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: Few studies directly compare outcomes between the most commonly used preservation solutions in pediatric heart transplantation in a large cohort of recipients. The purpose of this study is to investigate the effect of cardiac preservation solution on survival in pediatric heart transplant recipients. Methods: The United Network for Organ Sharing (UNOS) database was retrospectively reviewed from 01/2004‐03/2018 for pediatric donor hearts. Saline, University of Wisconsin (UW), "cardioplegia, " Celsior, and Custodiol preservation solutions were evaluated. The primary endpoints were recipient survival at 30 days, 1 year, and long term. Results: After exclusion criteria, 3012 recipients had preservation solution data available. The most common preservation solution used was UW in 1203 patients (40%), followed by Celsior in 542 (18%), cardioplegia in 461 (15%), saline in 408 (14%), and Custodiol in 398 (13%). Survival of recipients whose donor hearts were procured with UW was as follows: 97%—30 day, 92%—1 year; Celsior: 97%—30 day, 92%—1 year; cardioplegia: 97%—30 day, 91%—1 year; saline: 97%—30 day, 91%—1 year; and Custodiol: 96%—30 day and 92%—1 year. Analysis of Cox models for 30‐day and long‐term survival revealed no statistical differences when comparing UW to Celsior ( p = .333), cardioplegia ( p = .914), saline ( p = .980), or Custodiol ( p = .642) in adjusted models. Conclusions: There were no significant differences in 30‐day or 1‐year survival detected between commonly used preservation solutions in the pediatric heart transplant population.