Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect. Issue 11 (3rd April 2020)

• Record Type: Journal Article
• Authors: Toba, Monica N.; Zavaglia, Melissa; Malherbe, Caroline; Moreau, Tristan; Rastelli, Federica; Kaglik, Anna; Valabrègue, Romain; Pradat‐Diehl, Pascale; Hilgetag, Claus C.; Valero‐Cabré, Antoni
• Is Part Of: Human brain mapping. Volume 41:Issue 11(2020)
• Page Start: 2926
• Page End: 2950
• Publication Date: 2020-04-03
• Subjects: brain‐behavior relationships -- clinical anatomical correlations -- disconnection -- game theory -- lesion inference -- multiperturbation Shapley value analysis (MSA) -- neglect -- stroke -- visuospatial attention -- white matter; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.24987
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: White matter bundles linking gray matter nodes are key anatomical players to fully characterize associations between brain systems and cognitive functions. Here we used a multivariate lesion inference approach grounded in coalitional game theory (multiperturbation Shapley value analysis, MSA) to infer causal contributions of white matter bundles to visuospatial orienting of attention. Our work is based on the characterization of the lesion patterns of 25 right hemisphere stroke patients and the causal analysis of their impact on three neuropsychological tasks: line bisection, letter cancellation, and bells cancellation . We report that, out of the 11 white matter bundles included in our MSA coalitions, the optic radiations, the inferior fronto‐occipital fasciculus and the anterior cingulum were the only tracts to display task‐invariant contributions (positive, positive, and negative, respectively) to the tasks. We also report task‐dependent influences for the branches of the superior longitudinal fasciculus and the posterior cingulum. By extending prior findings to white matter tracts linking key gray matter nodes, we further characterize from a network perspective the anatomical basis of visual and attentional orienting processes. The knowledge about interactions patterns mediated by white matter tracts linking cortical nodes of attention orienting networks, consolidated by further studies, may help develop and customize brain stimulation approaches for the rehabilitation of visuospatial neglect. Abstract : We inferred causal contributions of white matter bundles to visuo‐spatial attention. We observed that the optic radiations and the inferior fronto‐occipital fasciculus exerted task‐invariant positive contributions to spatial attention, whereas the anterior cingulum provided task‐invariant negative ‐hindering‐ contributions. The superior longitudinal fasciculus and the corpus callosum displayed task‐dependent contributions. These results may inform future uses of brain stimulation approaches in visuospatial attention rehabilitation.