Cytotoxic and chemotaxonomic study of isolated metabolites from Centaurea aegyptiaca. Issue 1 (21st September 2020)

• Record Type: Journal Article
• Authors: Mohamed, Tarik A.; Elshamy, Abdelsamed I.; Abd‐ElGawad, Ahmed M.; Hussien, Taha A.; El‐Toumy, Sayed A.; Efferth, Thomas; Hegazy, Mohamed‐Elamir F.
• Is Part Of: Journal of the Chinese Chemical Society. Volume 68:Issue 1(2021)
• Page Start: 159
• Page End: 168
• Publication Date: 2020-09-21
• Subjects: Centaurea aegyptiaca -- chemosystematic significance -- cytotoxicity -- lignans -- monoterpene -- sesquiterpene lactones; Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.202000156
• Languages: English
• ISSNs: 0009-4536

Abstract

Abstract: The aerial parts of Centaureaa egyptiaca afforded 10 secondary metabolites including four sesquiterpene lactones; chlorohyssopifolin A (centaurepensin) (1 ), rediolpidetriol (2 ), linichlorinA (3 ), and sinaicin (4 ), one monoterpene; loliolid (5 ), one phenolic: tyrosol (6 ), three lignans; arctigenin (7 ), matairesinol (8 ), and pinoresinol (9 ), and one steroid; ergosta‐5, 22‐dien‐3‐ol (10 ). The cluster analysis of 32 Centaurea species revealed that C. aegyptiaca is closely related to C. repens and C. solstitialise . The isolated compounds (1 –10 ) were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53 + / + ) colon carcinoma cell lines. Compounds1 and 2 were the most potent compounds against both leukemia and breast carcinoma cell lines. Abstract : The aerial parts of Centaurea egyptiaca afforded 10 secondary metabolites and were screened against CCRF‐CEM‐leukemia, MDA‐MB‐231‐pcDNA3 breast cancer, and HCT116 (p53+/+) colon carcinoma cell lines. The cluster analysis of 32 Centaurea species revealed that C. aegyptiaca is closely related to C. repens and C. solstitialise. Compounds1 and 2 were the most potent compounds against both leukemia and breast carcinoma cell lines.