Remodeling of collagen constituting interlobular septa of subcutaneous adipose tissue following microwaves application. Issue 3 (8th April 2020)

• Record Type: Journal Article
• Authors: Zerbinati, Nicola; d'Este, Edoardo; Farina, Aurora; Cornaglia, Antonia I.; Jafferany, Mohammad; Golubovic, Masa; Binic, Iva; Sigova, Julia; Van Thuong, Nguyen; Tirant, Michael; Riva, Federica; Protasoni, Marina; Rauso, Raffaele; Lotti, Torello; Calligaro, Alberto
• Is Part Of: Dermatologic therapy. Volume 33:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-08
• Subjects: circularly polarized microscopy -- collagen remodeling -- fat reduction -- microwave device -- Picrosirius red; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/dth.13362
• Languages: English
• ISSNs: 1396-0296

Abstract

Abstract: In this study, the application of a recently introduced device based on electromagnetic energy transfer by microwaves for fat reduction, permitted to study specifically the modifications of thick fibrous collagen interlobular septa in the subcutaneous adipose tissue, related to the formation of large clusters of adipocytes. The use of Picrosirius red staining associated with circularly polarized microscopy gave evidence of appreciable modifications of the fibrous connective tissue forming septa. Compact fibrotic bundles of collagen I forming interlobular septa appeared reduced or dissolved, in part substituted by the increase of more diffuse and finely reticular collagen III. Remodeling of fibrous collagen, which formed bridles involved in the appearance at the surface of the skin of dimpling/orange peer pattern typical of cellulite, was observed.