Tribbles role in reproduction. (9th October 2015)

• Record Type: Journal Article
• Authors: Basatvat, Shaghayegh; Carter, Deborah Angela Louise; Kiss-Toth, Endre; Fazeli, Alireza
• Is Part Of: Biochemical Society transactions. Volume 43:Number 5(2015)
• Page Start: 1116
• Page End: 1121
• Publication Date: 2015-10-09
• Subjects: embryo implantation -- fertility -- innate immunity -- toll-like receptor signalling pathways -- tribbles; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20150121
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Tribbles (TRIB) proteins, a family of evolutionary conserved psuedokinase proteins, modulate various signalling pathways within the cell. The regulatory roles of TRIB make them an important part of a number of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte by spermatozoon and lasts throughout early embryonic development, pregnancy and labour. Therefore, there is a close cooperation between the reproductive system and the innate immune system. Evidence from our lab has demonstrated that improper activation of the innate immune system can reduce embryo implantation, thus leading to infertility. Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events.