Cycloisomerization of Pyridine‐Substituted Propargylic Alcohols or Esters To Construct Indolizines and Indolizinones. Issue 16 (16th March 2017)

• Record Type: Journal Article
• Authors: Wang, Li‐Xia; Tang, Ya‐Lin
• Is Part Of: European journal of organic chemistry. Issue 16(2017)
• Page Start: 2207
• Page End: 2213
• Publication Date: 2017-03-16
• Subjects: Cyclization -- Isomerization -- Nitrogen heterocycles -- Indolizines -- Indolizinones -- Propargylic alcohols -- Propargylic esters; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201601530
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Nitrogen‐containing heterocycles are found in a vast number of natural products and biologically active compounds, and have attracted a lot of attention. Among all the reported methods, cycloisomerization transformations involving the activation of alkynes with the aid of transition metals are a very active area in synthetic organic chemistry. This review covers the most important recent advances in the use of metal‐catalyzed or metal‐free cycloisomerizations for the preparation of indolizines and indolizinones from starting substrates consisting of pyridine‐containing propargylic esters or alcohols. Cycloisomerization transformations to heterocycles are very efficient and atom‐economic, and we hope that this review will result in further focused research to widen the application of indolizines and indolizinones. Abstract : Cycloisomerization transformations affording heterocycles are very efficient and atom‐economic. This review covers the most important recent advances in metal‐catalyzed or metal‐free cycloisomerizations to prepare indolizines and indolizinones from starting substrates consisting of pyridine‐containing propargylic esters or alcohols.