Targeting polysaccharides such as chitosan, cellulose, alginate and starch for designing hemostatic dressings. (1st September 2022)

• Record Type: Journal Article
• Authors: Wang, Liangyu; Hao, Fan; Tian, Saihua; Dong, Huifeng; Nie, Jun; Ma, Guiping
• Is Part Of: Carbohydrate polymers. Volume 291(2022)
• Publication Date: 2022-09-01
• Subjects: HDs hemostatic dressings -- FXIII Fibrin stabilizing factor -- vWFs von Willebrand Factors -- FXII surface factor, also known as Hageman factor -- APTT activated partial thromboplastin time -- FXI antihemophilic C globulin -- FIX antihemophilic B globulin -- FVII antihemophilic A globulin -- BC bacterial cellulose -- PEG polyethylene glycol -- FDA Food and Drug Administration -- PVA polyvinyl alcohol -- PCL polycaprolactone -- GelMA gelatin methacryloyl -- CDPE β-cyclodextrin polyester -- HEMA 2-hydroxyethyl methacrylate -- CNFs carbon nanofibers -- RAFT addition-fragmentation chain transfer polymerization -- HA hyaluronic acid -- VBP TRYLRIHPQSQVHQI, a kind of peptide -- IUPAC International Union of Pure and Applied Chemistry -- FXII surface factor -- CNTs carbon nanotubes -- RBCs red blood cells -- MMT montmorillonite -- TiO2 titanium dioxide -- rGO graphene oxide -- AgNPs silver nanoparticles -- -SH sulfhydryl groups -- TF tissue factor -- PPT photothermal therapy -- X autoprothrombin C -- V procoagulant fibrinogen -- VII thromboplastin -- WAC water absorption capacity -- ZP zeta potential -- AS adhesive strength -- BAC blood absorption capacity -- WAR water absorption rate -- BAR blood absorption rate -- GP gelling point -- BP burst pressure -- CO2 carbon dioxide -- ΔP pressure difference -- MSS negatively-modified-microporous starch -- BCA blood contact angle -- WCA water contact angle -- hm-chitosan hydrophobic modified chitosan -- α-CD α-cyclodextrin -- RCA rolling contact angle -- PTFE polytetrafluoroethylene -- PDMS polydimethylsiloxane -- PAA poly(acrylic acid) -- IT interfacial toughness -- TA Tannins -- SF silk fibroin -- ECM extracellular matrix -- NB N-(2-aminoethyl)–4-(4-(hydroxymethyl)–2-methoxy-5-nitrosophenoxy) butanamide -- UV ultraviolet -- LBA liquid bandage -- TAs tissue adhesive -- EDC 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride; -- sulfo-NHS N-hydroxysulfosuccinimide -- EC European Commission -- POx poly(2-oxazoline)s -- DST double-sided tape -- pNIPAM poly(N-isopropyl acrylamide) -- SBC sodium bicarbonate -- GSH glutathione -- ATRP atom transfer radical polymerization -- NMP nitroxide-mediated polymerization; Hemostasis -- Polysaccharide -- Hemostatic mechanism -- Hemostatic dressing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119574
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Unfortunately hemorrhage and its complications (e.g. anemia, organ failure, and hypothermia) induced by traumatic injury, surgery, and disorders of bleeding play an all too familiar role in human morbidity and mortality. Therefore, it is difficult to overstate the importance of better understanding the role of polysaccharides in advanced hemostatic dressings (HDs). This review includes consideration of polysaccharide hemostatic dressing mechanism of action, relative efficacy, cost and safety. Polysaccharide-based HDs are widely used in management not only of external and internal bleeding but also of massive hemorrhage. These polysaccharide-based HDs have been shown to be effective in both compressible and non-compressible hemorrhage. Hemostatic dressings are designed with different principles depending on location and extent of injury. This review focuses on polysaccharide HD design and associated hemostatic mechanisms. It addresses current issues, challenges, and future perspectives. Graphical abstract: Unlabelled Image