Recent advances in managing chemotherapy-induced peripheral neuropathy: A systematic review. (June 2022)

• Record Type: Journal Article
• Authors: Wang, Mian; Pei, Ziwen; Molassiotis, Alex
• Is Part Of: European journal of oncology nursing. Volume 58(2022)
• Publication Date: 2022-06
• Subjects: Cancer -- Chemotherapy-induced peripheral neuropathy -- Pain -- Symptom management -- Systematic review; Cancer -- Nursing -- Periodicals; Cancer -- Research -- Periodicals; Oncology -- Periodicals; Oncology Nursing -- Periodicals; Neoplasms -- nursing -- Periodicals; Cancer -- Soins infirmiers -- Périodiques; Cancer -- Recherche -- Périodiques; Cancérologie -- Périodiques; Verpleegkunde; Kanker; Cancer -- Nursing; Cancer -- Research; Oncology; Electronic journals; Periodicals; Electronic journals; 616.9940231
• DOI: 10.1016/j.ejon.2022.102134
• Languages: English
• ISSNs: 1462-3889

Abstract

Abstract: Purpose: The aim in this review was to explore recent advances in chemotherapy-induced peripheral neuropathy (CIPN) management interventions and to identify the implications for practice and future research. Methods: A comprehensive search through seven electronic databases (AMED, CINAHL, Cochrane Library, EMBASE, PEDro, PubMed, and Web of Science) was conducted for studies published between January 1, 2013 and August 3, 2019. An updated search for subsequently published studies was made through PubMed on February 15, 2022. Randomized controlled trials (RCTs) involving either pharmacological or non-pharmacological interventions were considered eligible. The Cochrane Risk of Bias tool version 2.0 (RoB 2.0) was used to appraise the methodological risk of bias. Data extracted from the included RCTs were synthesized in a narrative approach. Results: Forty-two RCTs involving a total of 3393 participants were included. Overall, a high risk of bias was found in most of the included RCTs. The results further confirmed the analgesic effect of duloxetine on pain-related to CIPN. Exercise-based interventions, acupuncture, and several non-invasive neuromodulation techniques showed promise for managing CIPN. Conclusions: The effects of most pharmacological and non-pharmacological interventions on CIPN are inconclusive due to methodological issues. Duloxetine remains the only pharmacological intervention recommended for managing pain related to CIPN. Although definitive recommendations cannot be made based on current research evidence, non-pharmacological interventions, especially non-invasive neuromodulation techniques, warrant future research. Highlights: Duloxetine remains the only recommended pharmacological intervention for managing pain related to CIPN. Non-pharmacological interventions seem to be more promising for managing established CIPN than pharmacological interventions. Non-invasive neuromodulation techniques warrant future investigation.