Reliability of relaxation properties of knee-extensor muscles induced by transcranial magnetic stimulation. (21st June 2022)

• Record Type: Journal Article
• Authors: Vernillo, Gianluca; Barbi, Chiara; Temesi, John; Giuriato, Gaia; Giuseppe Laginestra, Fabio; Martignon, Camilla; Schena, Federico; Venturelli, Massimo
• Is Part Of: Neuroscience letters. Volume 782(2022)
• Publication Date: 2022-06-21
• Subjects: Fatigue -- Knee extensors -- Reliability -- Transcranial magnetic stimulation -- Muscle relaxation rate; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2022.136694
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Transcranial magnetic stimulation (TMS)-induced muscle relaxation demonstrates high within- and between-session reliability in unfatigued and fatigued knee-extensor muscles. TMS is a useful technique that researchers can use when investigating changes in muscle relaxation rates both in unfatigued and fatigued knee-extensor muscles. In both healthy individuals and patient groups, TMS-induced muscle relaxation could be used for therapy effect monitoring and diagnostic purposes. Abstract: Transcranial magnetic stimulation (TMS)-induced relaxation rate reflects intrinsic muscle contractile properties by interrupting the drive from the central nervous system during voluntary muscle contractions. To determine the appropriateness of knee-extensor muscle relaxation measurements induced by TMS, this study aimed to establish both the within- and between-session reliability before and after a fatiguing exercise bout. Eighteen participants (9 females, 9 males, age 25 ± 2 years, height 171 ± 9 cm, body mass 68.5 ± 13.5 kg) volunteered to participate in two identical sessions approximately 30 days apart. Maximal and submaximal neuromuscular evaluations were performed with TMS six times before (PRE) and at the end (POST) of a 2-min sustained maximal voluntary isometric contraction. Within- and between-session reliability of PRE values were assessed with intraclass correlation coefficient (ICC2, 1, relative reliability), repeatability coefficient (absolute reliability), and coefficient of variation (variability). Test-retest reliability of post-exercise muscle relaxation rates was assessed with Bland-Altman plots. For both the absolute and normalized peak relaxation rates and time to peak relaxation, data demonstrated low variability (e.g. coefficient of variation ≤ 7.8%) and high reliability (e.g. ICC2, 1 ≥ 0.963). Bland-Altman plots showed low systematic errors. These findings establish the reliability of TMS-induced muscle relaxation rates in unfatigued and fatigued knee-extensor muscles, showing that TMS is a useful technique that researchers can use when investigating changes in muscle relaxation rates both in unfatigued and fatigued knee-extensor muscles.