Validation of items on the NDDIE and PHQ-9 associated with suicidal ideation during suicidality screening in patients with epilepsy. (July 2022)

• Record Type: Journal Article
• Authors: Kim, Hyo Jae; Jeon, Ji-Ye; Kim, Hyun-Woo; Lee, Sang-Ahm
• Is Part Of: Seizure. Volume 99(2022)
• Page Start: 99
• Page End: 104
• Publication Date: 2022-07
• Subjects: Epilepsy -- Suicidality -- PHQ-9 -- NDDIE -- Suicidal ideation; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2022.05.011
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: Item 4 on the NDDIE and item 9 on the PHQ-9 represent suicidal ideation. Items related to suicidal ideation show the best psychometric properties for screening suicidality. The specificities of these items are increased in patients with depression. Abstract: Purpose: : This study was performed to validate individual items on the Neurological Disorders Depression Inventory for Epilepsy (NDDIE) and the Patient Health Questionnaire-9 (PHQ-9), as well as their total scores, during suicidality screening of patients with epilepsy (PWE). Methods: : PWE were assessed with the Mini International Neuropsychiatric Interview (MINI), the NDDIE, and the PHQ-9. Moderate to high suicidality, as assessed by the Suicidality Module of the MINI, was considered the standard measurement. Each item and overall scores for the NDDIE and PHQ-9 were evaluated by receiver operating characteristic (ROC) curve analyses. The optimal cutoff criteria were identified as those with the highest Youden index. Results: : Of the 213 participants, 20 (9.4%) had moderate to high suicidality. Item 4 on the NIDDE and item 9 on the PHQ-9, representing suicidal ideation, showed the best psychometric properties for suicidality. A cutoff of >1 for item 4 on the NDDIE showed an area under the ROC curve (AUC) of 0.853, a sensitivity of 90.0%, and a specificity of 72.0%. A cutoff >0 for item 9 on the PHQ-9 showed an AUC of 0.851, a sensitivity of 90.0%, and a specificity of 74.6%. The specificities and positive predictive values of item 4 on the NDDIE and item 9 on the PHQ-9 were higher in patients with depression than those in the overall patient population. Conclusion: : Item 4 of NDDIE and Item 9 of PHQ-9 showed value in screening for suicidality. Use of these items may rapidly identify suicidality among PWE.