Hyperbaric oxygen regulates tumor mechanics and augments Abraxane and gemcitabine antitumor effects against pancreatic ductal adenocarcinoma by inhibiting cancer-associated fibroblasts. (June 2022)

• Record Type: Journal Article
• Authors: Wang, Xiaoxian; Ye, Ningbing; Xu, Chen; Xiao, Chen; Zhang, Zhijie; Deng, Qingyuan; Li, Shiyou; Li, Jiayuan; Li, Zifu; Yang, Xiangliang
• Is Part Of: Nano today. Volume 44(2022)
• Publication Date: 2022-06
• Subjects: Pancreatic ductal adenocarcinoma -- Tumor mechanics -- Cancer-associated fibroblasts -- Cancer stem cells -- Hyperbaric oxygen -- Cancer therapy; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2022.101458
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: While the combination of Abraxane and gemcitabine (GEM) has been approved as a first-line therapy for the treatment of advanced pancreatic ductal carcinoma (PDAC), the clinical antitumor efficacy is dismal thus far. Here, we explore hyperbaric oxygen (HBO) therapy to boost antitumor efficacy of Abraxane and GEM against murine PDAC Panc02 tumors. Mechanistically, we reveal that HBO significantly constrains cancer-associated fibroblasts (CAFs) by disrupting hypoxia. As CAFs are the main producers of extracellular matrix (ECM) components, HBO effectively reduces collagen Ⅰ and fibronectin, leading to normalization of not only tumor mechanics but also blood vessels. Therefore, HBO augments drug delivery in terms of tumor accumulation, penetration, and cellular internalization. Furthermore, we demonstrate that HBO helps Abraxane and GEM eliminate cancer stem cells (CSCs) by regulating CAFs mediated CSCs niche. Consequently, HBO potentiates antitumor efficacy of Abraxane and GEM by inhibiting not only primary tumors but more importantly metastases of Panc02 tumors, with negligible side effects. Given HBO, Abraxane, and GEM are routinely applied in clinical practice, their combination is readily translatable to bedside applications. Graphical Abstract: ga1 Highlights: Hyperbaric oxygen depletes cancer-associated fibroblasts by overcoming tumor hypoxia. Hyperbaric oxygen normalizes tumor mechanics in pancreatic ductal adenocarcinoma. Hyperbaric oxygen disrupts cancer-associated fibroblasts-mediated cancer stem cell niche. Hyperbaric oxygen boosts antitumor efficacy of Abraxane and gemcitabine.