Piezoelectric materials for synergistic piezo- and radio-catalytic tumor therapy. (June 2022)

• Record Type: Journal Article
• Authors: Liao, You; Wang, Dongmei; Zhu, Shuang; Zhou, Ruyi; Rahbarizadeh, Fatemeh; Gu, Zhanjun
• Is Part Of: Nano today. Volume 44(2022)
• Publication Date: 2022-06
• Subjects: Piezoelectric materials -- Radiosensitization -- Radiocatalysis -- Piezoelectric catalysis -- Synergistic therapies; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2022.101510
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: Radio-catalytic therapy (RCT) is emerging as a split-new sensitization modality for photon radiotherapy. However, the outcome of RCT is greatly hurdled by the insufficient intracellular catalytic substrates such as H2 O2 . Here we provided a synergistic oncotherapy strategy that utilized BiOCl-based piezoelectric nanocatalysts to successively mediate medical ultrasound and X-rays for piezo- and radio-catalytic tumor suppression. First, BiOCl-based nanocatalysts were able to mediate piezo-catalysis under ultrasound excitation to achieve wireless in-situ supply of H2 O2 . Subsequently, due to the role of the electronic sacrificial agent of H2 O2, radio-catalytic hydroxyl radical generation of BiOCl-based nanocatalysts upon X-ray irradiation was significantly accelerated. The elevated free radicals via synergistic dual-catalysis could cause serious damage to tumor cells. Furthermore, such a synergistic effect in vivo of piezo- and radio-catalysis inducing a maximized tumor suppression was also confirmed. Together, this work provided a potent strategy of the in-situ intratumoral H2 O2 supply for boosting radio-catalytic cancer therapy, simultaneously broadening the scope of piezoelectric materials in biomedical application. Graphical Abstract: ga1 Highlights: ● Piezoelectric materials were applied as both sonosensitizers and radiosensitizers for the first time. ● In-situ H2 O2 supply was achieved by the piezocatalyst within the tumor under the driving of medical ultrasound. ● H2 O2 supply from piezocatalysis accelerated the radiocatalytic free radical generation. ● A potential tumor therapeutic strategy supported by piezoelectric materials-mediated dual catalysis was proposed.