26 CORRELATION BETWEEN DIABETES-RELATED CLINICAL INDICES AND PULSE WAVE VELOCITY IN TYPE 2 DIABETES PATIENTS WITH HYPERTENSION. (May 2022)

• Record Type: Journal Article
• Authors: Khumaedi, Anandhara Indriani; Nugroho, Pringgodigdo; Purnamasari, Dyah
• Is Part Of: Journal of hypertension. Volume 40(2022)Supplement 2
• Page Start: e7
• Publication Date: 2022-05
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000832984.43845.68
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Background and Objective: It is known that arterial stiffness, an early vascular changes index, is influenced by diabetes and hypertension. It is also a strong predictor to mortality in type 2 diabetes melitus (T2DM). This study was aimed to see correlation of diabetes-related indices with pulse wave velocity (PWV) in patients with T2DM and hypertension. Method: This is cross sectional study involving T2DM patients with hypertension in endocrinology clinic in RSCM. Blood pressure was measured using Omronâ automatic sphygmomanometer. Central Pulse Pressure (CPP), amplification and PWV was measured using SphygmoCorâXCEL. Diabetes-related parameters measured in this study are duration, A1C and albumin-to-creatinine ratio (ACR). Result: Out of 47 subjects, most of them are female (68%), median age 51years (IQR 10, 50), median waist circumference (WC) 96 cm (IQR 9, 6) and mean BMI 27 kg/m 2 (SD 3, 90). Median systolic is 153mmHg (IQR 15), diastolic 91mmHg (IQR 92), amplification 18mmHg (SD 6, 0) and median CPP 43mmHg (IQR 12). Mean PWV is 7, 5 m/s (SD 1, 22). Subjects showed inadequate control of diabetes (median A1C 7, 8% [IQR 2, 8]) and macroalbuminuria (median ACR 763 mg/grCr [IQR 2, 8]). We found positive correlation between PWV and SBP (r=0, 312;p=0, 016), amplification (r=0.370;p=0, 05), CPP (r=0, 370;p=0, 007), diabetes duration (r=0, 476;p<0, 005), A1c (r=0, 417;p=0, 002), ACR (r=0, 511;p<0, 005) and WC (r=0, 290;p=0, 024). Multivariate analysis showed weak association between PWV and WC, CPP and diabetes duration (R 2 =0, 338). Conclusion: In this study, ACR and A1c didn't show direct significant relationship to PWV. Systolic amplification may mediate the relationship between ACR and A1c to PWV, since these indices associated with vascular changes. This emphasized the importance of BP control for preventing CV events in T2DM.