ASSOCIATIONS OF LONG-TERM VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY WITH SUBCLINICAL RENAL DAMAGE AND ALBUMINURIA IN ADULTHOOD: A 30-YEAR PROSPECTIVE COHORT STUDY. (June 2022)

• Record Type: Journal Article
• Authors: Wang, Yang; Mu, Jian-Jun; Zhao, Peng; Chu, Chao; Du, Ming-Fei; Zou, Ting; Hu, Gui-Lin; Liao, Yue-Yuan; Chen, Chen; Ma, Qiong; Wang, Dan; Wang, Ke-Ke; Chen, Fang-Yao
• Is Part Of: Journal of hypertension. Volume 40(2022)Supplement 1
• Page Start: e46
• Publication Date: 2022-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000835648.48914.e3
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To determine the potential associations of long-term BPV from childhood to middle age with subclinical renal damage (SRD) and albuminuria in adulthood, independently of mean BP and cumulative exposure to BP. Design and method: Using data from the ongoing cohort of Hanzhong Adolescent Hypertension study, which recruited children and young adults aged 6 to 18 years at baseline, we assessed BP variability by standard deviation (SD) and average real variability (ARV) for 30 years (6 visits). Results: During a follow-up of 30 years, of the 1115 participants, 146 SRD events occurred. After adjustment for demographic, clinical characteristics and mean BP during 30 years, higher SDSBP, ARVSBP, SDDBP, ARVDBP, SDMAP and ARVMAP were significantly associated with higher risk of SRD [ORs (95% CIs) were 1.06(1.03–1.10), 1.12(1.06–1.19), 1.17(1.11–1.23), 1.22(1.13–1.32), 1.13(1.08, 1.19) and 1.21(1.12–1.31), respectively]. When we used cumulative exposure to BP from childhood to adulthood instead of mean BP as adjustment factors, results were similar. In addition, greater long-term BPV was also associated with the risk of albuminuria [ORs (95% CIs) were 1.06(1.12–1.10) for SDSBP, 1.12(1.06–1.19) for ARVSBP, 1.14(1.08–1.21) for SDDBP, 1.19(1.10–1.30) for ARVDBP, 1.13(1.07–1.19) for SDMAP, and 1.20(1.11–1.32) for ARVMAP] adjusting for demographic, clinical characteristics, mean BP or cumulative exposure to BP during 30 years. Conclusions: Long-term BP variability for 30 years from childhood to middle age was associated with higher risk of subclinical renal damage and albuminuria in adulthood, independent of mean BP or cumulative exposure to BP during follow-up. Identifying long-term BP variability from early age may assist in predicting renal disease and cardiovascular disease in later life.