MORPHOFUNCTIONAL ABNORMALITIES WITHIN THE AORTA AS A PREDICTOR OF ARTERIAL HYPERTENSION IN METABOLIC SYNDROME. (June 2022)

• Record Type: Journal Article
• Authors: Birulina, Yuliya; Buyko, Evgeniy; Ivanov, Vladimir; Dzyuman, Anna; Grigoreva, Anna
• Is Part Of: Journal of hypertension. Volume 40(2022)Supplement 1
• Page Start: e214
• Publication Date: 2022-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000837644.19267.86
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Arterial hypertension is an important component of the metabolic syndrome, the development of which is caused by the occurrence of endothelial dysfunction and impaired contractile activity of vascular smooth muscle cells. In the presented work, the morphological basis of an increase in blood pressure under the influence of a high-fat high-carbohydrate diet in rats was investigated. Design and method: A study was carried out in male Wistar rats weighing 250–320 g, 140 days old at the end of research. The rats from the control group were fed standard rat chow. The rats from the experimental group had a high-fat high-carbohydrate diet (proteins 16%, fats 21%, carbohydrates 46%, including 17% fructose, 0.125% cholesterol, 90 days). Body weight, blood pressure were assessed. It was determined the morphological changes in the aortic wall. Mechanical tension of isolated aortic rings was measured by Myobath Tissue Bath System II. Sections of aorta were stained with hematoxylin and eosin, sudan III. Results: It was found that blood pressure increases in animals kept on a high-carbohydrate high-fat diet. The high-carbohydrate high-fat diet causes endothelial vascular dysfunction, impaired contractile activity of vascular smooth muscles. In the rats the experimental group a changes in the activity of calcium and potassium channels, Na +, K +, 2Cl - cotransporter and chlorine conductivity was found. In the aortic wall of the animals of the experimental group, there are signs of elastolysis (initial remodeling of the media), accumulation of lipids in the interstitial cells of the media, hyperplasia of fat cells in the adventitia. Conclusions: Functional and morphological abnormalities in the vascular wall in metabolic syndrome can be the basis for an increase in blood pressure and arterial hypertension.