1393. A Phase 1, Randomized, Open-Label, Crossover Study in Healthy Subjects Under Fasting Conditions of Orally Administered Sulopenem Etzadroxil Alone or with Probenecid to Determine the Pharmacokinetics of Sulopenem. (26th November 2018)

• Record Type: Journal Article
• Authors: Dunne, Michael; Aronin, Steven; Dunzo, Elise; Puttagunta, Sailaja
• Is Part Of: Open forum infectious diseases. Volume 5(2018)Supplement 1
• Page Start: S428
• Page End: S429
• Publication Date: 2018-11-26
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofy210.1224
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Antimicrobial resistance to available oral antibiotics is becoming progressively more common, precipitating the need for additional treatment options as step‐down from initial intravenous (IV) therapy as well as for treatment of infections in the community. Sulopenem (CP‐70, 429) is a thiopenem antibiotic active against quinolone non‐susceptible and ESBL‐producing Enterobacteriaceae. As the key pharmacokinetic‐pharmacodynamic variable correlating with efficacy for penem antibiotics is time above minimum inhibitory concentration (T > MIC), we examined the utility of probenecid, an OAT‐1 inhibitor of β‐lactam excretion, on the pharmacokinetic (PK) parameters for the oral prodrug of sulopenem, sulopenem etzadroxil Methods: Twelve healthy males and females received a single oral dose of 500 mg sulopenem etzadroxil as powder in bottle either alone or co‐administered with a single oral dose of probenecid 500 mg in a crossover design with a washout period of 6 days. All doses were administered under fasting conditions. Blood samples for plasma PK analysis were collected and PK parameters for sulopenem, the parent compound of sulopenem etzadroxil, were determined. Results: Treatment Conclusion: Probenecid increases the AUC of sulopenem by 28% in the fasted state and extends the mean time over MIC. Disclosures: M. Dunne, Iterum Therapeutics: Employee and Shareholder, Salary. S. Aronin, Iterum Therapeutics: Employee and Shareholder, Salary. E. Dunzo, Parexel: Consultant, Consulting fee. S. Puttagunta, Iterum Therapeutics: Employee and Shareholder, Salary.