B7-H3 and Its Role in Antitumor Immunity. (28th November 2010)

• Record Type: Journal Article
• Authors: Loos, Martin; Hedderich, Dennis M.; Friess, Helmut; Kleeff, Jörg
• Other Names: Pauza C. D. Academic Editor.
• Is Part Of: Clinical & developmental immunology. Volume 2010(2010)
• Publication Date: 2010-11-28
• Subjects: Developmental immunology -- Periodicals; Clinical immunology -- Periodicals; Immune System -- immunology -- Periodicals; Immune System -- growth & development -- Periodicals; Immune System Diseases -- immunology -- Periodicals; 571.9638
• DOI: 10.1155/2010/683875
• Languages: English
• ISSNs: 1740-2522

Abstract

Abstract : B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.