Radiating the prostate bed in relapsed oligometastatic prostate cancer: How comprehensive should we be?. Issue 5 (11th January 2022)
- Record Type:
- Journal Article
- Title:
- Radiating the prostate bed in relapsed oligometastatic prostate cancer: How comprehensive should we be?. Issue 5 (11th January 2022)
- Main Title:
- Radiating the prostate bed in relapsed oligometastatic prostate cancer: How comprehensive should we be?
- Authors:
- Cao, Yilin
Song, Daniel Y.
Deville, Curtiland
DeWeese, Theodore L.
Greco, Stephen
Tran, Phuoc T.
Deek, Matthew P. - Abstract:
- Abstract: Purpose: A subset of patients with high‐risk pathological features at radical prostatectomy recur with oligometastatic disease. The aim of this study is to investigate the rate of prostate bed recurrence, with or without history of prostate bed irradiation (PBRT), in oligometastatic prostate cancer (OMPC) patients after metastasis‐directed therapy (MDT). Methods: We performed a retrospective analysis of hormone‐sensitive OMPC patients treated initially with curative‐intent radical prostatectomy followed by disease recurrence and metastasis‐directed stereotactic ablative radiotherapy (SABR) at our institution. Prostate bed recurrence rates were compared between patients who had PBRT at any point (i.e., before oligometastatic diagnosis or concurrently with MDT) versus those with no history of PBRT. Results: Seventy‐seven patients were included, and 68.8% had received PBRT. There were no significant differences in baseline characteristics between those who had received and had not received PBRT. There were five prostate bed recurrences following MDT, specifically with a 24‐month cumulative incidence of 30.4% in patients who did not have PBRT and 2.4% in those who did ( p = 0.03). Three of the five recurrences were isolated to the prostate bed at time of recurrence. Conclusions: Relapsed oligometastatic prostate cancer patients who have not received maximal local consolidative therapy to the prostate bed may have higher rates of local failure. Prospective studies areAbstract: Purpose: A subset of patients with high‐risk pathological features at radical prostatectomy recur with oligometastatic disease. The aim of this study is to investigate the rate of prostate bed recurrence, with or without history of prostate bed irradiation (PBRT), in oligometastatic prostate cancer (OMPC) patients after metastasis‐directed therapy (MDT). Methods: We performed a retrospective analysis of hormone‐sensitive OMPC patients treated initially with curative‐intent radical prostatectomy followed by disease recurrence and metastasis‐directed stereotactic ablative radiotherapy (SABR) at our institution. Prostate bed recurrence rates were compared between patients who had PBRT at any point (i.e., before oligometastatic diagnosis or concurrently with MDT) versus those with no history of PBRT. Results: Seventy‐seven patients were included, and 68.8% had received PBRT. There were no significant differences in baseline characteristics between those who had received and had not received PBRT. There were five prostate bed recurrences following MDT, specifically with a 24‐month cumulative incidence of 30.4% in patients who did not have PBRT and 2.4% in those who did ( p = 0.03). Three of the five recurrences were isolated to the prostate bed at time of recurrence. Conclusions: Relapsed oligometastatic prostate cancer patients who have not received maximal local consolidative therapy to the prostate bed may have higher rates of local failure. Prospective studies are warranted investigating when prostate bed irradiation should be considered for patients after radical prostatectomy who ultimately have oligometastatic prostate cancer. … (more)
- Is Part Of:
- Prostate. Volume 82:Issue 5(2022)
- Journal:
- Prostate
- Issue:
- Volume 82:Issue 5(2022)
- Issue Display:
- Volume 82, Issue 5 (2022)
- Year:
- 2022
- Volume:
- 82
- Issue:
- 5
- Issue Sort Value:
- 2022-0082-0005-0000
- Page Start:
- 551
- Page End:
- 555
- Publication Date:
- 2022-01-11
- Subjects:
- metastasis‐directed radiation therapy -- oligometastatic -- prostate bed irradiation
Prostate -- Diseases -- Periodicals
616 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0045 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/pros.24301 ↗
- Languages:
- English
- ISSNs:
- 0270-4137
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6935.194000
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- 21953.xml