Initial Derivation of a Predictive Model for Left Ventricular Longitudinal Strain (LS) in Early Sepsis. (August 2022)

• Record Type: Journal Article
• Authors: Knox, Daniel B.; Lanspa, Michael J.; Wilson, Emily; Haaland, Benjamin; Beesley, Sarah; Hirshberg, Eliotte; Abraham, Theodore P.; Vallabhajosyula, Saraschandra; Grissom, Colin K.; Drakos, Stavros G.; Brown, Samuel M.
• Is Part Of: Journal of intensive care medicine. Volume 37:Number 8(2022)
• Page Start: 1049
• Page End: 1054
• Publication Date: 2022-08
• Subjects: sepsis -- cardiomyopathy -- deformation imaging -- longitudinal strain; Critical care medicine -- Periodicals; Critical Care -- Periodicals; Soins intensifs -- Périodiques; Soins intensifs; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.02805
• DOI: 10.1177/08850666211053796
• Languages: English
• ISSNs: 0885-0666

Abstract

Septic shock is a common deadly disease often associated with cardiovascular dysfunction. Left ventricular longitudinal strain (LV LS) has been proposed as a sensitive marker to measure cardiovascular function; however, it is not available universally in standard clinical echocardiograms. We sought to derive a predictive model for LV LS, using machine learning techniques with the hope that we may uncover surrogates for LV LS. We found that left ventricular ejection fraction, tricuspid annular plane systolic excursion, sepsis source, height, mitral valve Tei index, LV systolic dimension, aortic valve ejection time, and peak acceleration rate were all predictive of LV LS in this initial exploratory model. Future modeling work may uncover combinations of these variables which may be powerful surrogates for LV LS and cardiovascular function.