High-dose femtosecond-scale gamma-ray beams for radiobiological applications. (21st April 2022)

• Record Type: Journal Article
• Authors: McAnespie, C A; Streeter, M J V; Rankin, M; Chaudhary, P; McMahon, S J; Prise, K M; Sarri, G
• Is Part Of: Physics in medicine & biology. Volume 67:Number 8(2022)
• Publication Date: 2022-04-21
• Subjects: FLASH -- inverse compton scattering -- radiobiology -- ultra-high dose-rate; Biophysics -- Periodicals; Medical physics -- Periodicals; 610.153
• DOI: 10.1088/1361-6560/ac5bfd
• Languages: English
• ISSNs: 0031-9155

Abstract

Abstract: Objective . In the irradiation of living tissue, the fundamental physical processes involved in radical production typically occur on a timescale of a few femtoseconds. A detailed understanding of these phenomena has thus far been limited by the relatively long duration of the radiation sources employed, extending well beyond the timescales for radical generation and evolution. Approach . Here, we propose a femtosecond-scale photon source, based on inverse Compton scattering of laser-plasma accelerated electron beams in the field of a second scattering laser pulse. Main results . Detailed numerical modelling indicates that existing laser facilities can provide ultra-short and high-flux MeV-scale photon beams, able to deposit doses tuneable from a fraction of Gy up to a few Gy per pulse, resulting in dose rates exceeding 10 13 Gy/s. Significance . We envisage that such a source will represent a unique tool for time-resolved radiobiological experiments, with the prospect of further advancing radio-therapeutic techniques.