Highly Sensitive and Selective Sensing Probe for Determination of Anti-Covid-19 Remdesvir: Application to Pharmaceutical Dosage Form and Biological Fluids. Issue 2 (1st February 2022)

• Record Type: Journal Article
• Authors: Rizk, M.; Sultan, Maha A.; Tawfik, Basma M.; El-Eryan, Rasha Th.
• Is Part Of: Journal of the Electrochemical Society. Volume 169:Issue 2(2022)
• Publication Date: 2022-02-01
• Subjects: Electrochemistry -- Periodicals; 541.3705
• DOI: 10.1149/1945-7111/ac53ca
• Languages: English
• ISSNs: 0013-4651

Abstract

Abstract : We reported the first investigational electrochemical study for Remdesvir (REM). REM is a promising antiviral agent used recently for the treatment of the most dangerous pandemic disease nowadays (COVID-19). Anionic surfactant, silica nanoparticles, and multiwall carbon nanotubes modified carbon paste (SDS/SiO2 /MWCNT/CPE) sensor was designed to introduce our approach. The results revealed irreversible diffusion oxidative reaction of REM with two well-defined peaks (E1 /V = 1.19, E2 /V = 1.35) in 0.1 M phosphate buffer of pH 6 using differential pulse (DP) voltammetry. A linear relationship between the peak current and the drug concentration was established over the concentration range of 1.66 × 10 −7 − 3.52 × 10 −6 M (100 – 200 ng ml −1 ) with a limit of detection (LOD) of 4.80 × 10 −8 M and limit of quantitation (LOQ) of 8.0 × 10 −8 M and mean % recovery ± % RSD of 99.05 ± 1.94. The proposed method succeeded in the determination of the drug in its pharmaceutical dosage form, in human plasma with and human urine samples. Finally, the method was validated according to ICH guidelines and FDA guidance for the determination of the drug in biological fluids. The developed data was found to be in good agreement with a validated reported method.