Association of serum eicosapentaenoic acid to arachidonic acid ratio with microalbuminuria in a population of community-dwelling Japanese. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Fukami, Ako; Adachi, Hisashi; Hirai, Yuji; Enomoto, Mika; Otsuka, Maki; Kumagai, Eita; Nakamura, Sachiko; Yoshimura, Ayako; Obuchi, Aya; Nohara, Yume; Nakao, Erika; Hori, Kensuke; Fukumoto, Yoshihiro
• Is Part Of: Atherosclerosis. Volume 239:Issue 2(2015)
• Page Start: 577
• Page End: 582
• Publication Date: 2015-04
• Subjects: EPA -- AA -- EPA/AA ratio -- Microalbuminuria -- Epidemiology; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.02.033
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background: Epidemiological evidence suggests that the increased intake of omega-3 polyunsaturated fatty acids can prevent atherosclerosis-related cardiovascular diseases. Recently, serum eicosapentaenoic acid to arachidonic acid (EPA/AA) ratio has been reported to be a predictive marker of cardiovascular events. Accordingly, we examined the relationship between serum EPA/AA ratio and microalbuminuria. Methods: We enrolled 444 residents (174 males and 270 females, mean age 66.6 ± 9.3 years) who underwent a physical examination in Uku town (fishing area) in Japan. They received blood tests including serum levels of EPA and AA, and urine test to examine microalbuminuria. Eating and drinking patterns were evaluated by a brief self-administered diet history questionnaire. Microalbuminuria was defined as a urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g Cr. Results: The mean EPA/AA ratio was 0.66 ± 0.3 in males and 0.51 ± 0.2 in females. Multiple stepwise regression analyses revealed that systolic blood pressure (p < 0.0001), high sensitive C-reactive protein (p < 0.01), serum EPA/AA ratio (p < 0.01, inversely), and hemoglobin A1c (p < 0.05) were significantly associated with microalbuminuria. In the group with low serum EPA/AA ratio, the prevalence of microalbuminuria was significantly higher than the other, after the adjustments for confounding factors (odds ratio, 3.45; 95% confidence interval, 1.47–8.13; p < 0.01). Conclusion: The present study demonstrated that serum EPA/AA ratio was strongly associated with microalbuminuria. Highlights: We demonstrated the strong association of EPA/AA ratio and microalbuminuria. In low serum EPA/AA ratio group, the prevalence of microalbuminuria was higher than the other. The cut-off levels of EPA/AA ratio for the prevalence of microalbuminuria was 0.35 by ROC curves.