Smartphone-Based and Miniaturized Electrochemical Biosensing System for L-Lactate Detection. Issue 4 (1st April 2022)

• Record Type: Journal Article
• Authors: Yu, Qiwen; Chen, Jing; Xu, Jingpin; Chen, Long; Song, Yanhua; Xie, Xiaoya; Jin, Jinjiang; Liu, Hong; Liu, Jun; Zhang, Fengjiang; Chen, Xing
• Is Part Of: Journal of the Electrochemical Society. Volume 169:Issue 4(2022)
• Publication Date: 2022-04-01
• Subjects: L-lactate sensors -- real-time detection -- smartphone -- portable instrument -- screen-printed electrodes -- electrochemistry; Electrochemistry -- Periodicals; 541.3705
• DOI: 10.1149/1945-7111/ac6322
• Languages: English
• ISSNs: 0013-4651

Abstract

Abstract : Real-time detection of L-lactate is crucial in monitoring tissue oxygenation and organ metabolism in surgery patients during the perioperative period. Traditional commercial L-lactate detection techniques using bulky and expensive instruments are time-consuming, hindering timely feedback in the operating room. Herein, utilizing the modified screen-printed carbon electrode, a portable and user-friendly smartphone-based electrochemical biosensing system, integrated with a miniaturized potentiostat via wireless transmission, was successfully constructed for bedside detection of L-lactate. It has a wide sensing range from 0.05–10 mM and a low limit of detection (9.1 μ M). Bland–Altman analysis shows an acceptable agreement with the values of a mean difference (0.114 ± 0.3482) between results obtained with the commercial blood gas analysis instrument and the developed portable system. Accordingly, the developed portable system exhibits a great potential in point-of-care testing owing to its portability and rapid response in L-lactate detection during perioperative monitoring.