Rechallenge with Amisulpride in a Patient with Schizophrenia following a Manic Episode during Previous Therapy. (16th May 2022)

• Record Type: Journal Article
• Authors: Hu, Li-Yu; Hong, Chen-Jee; Tsai, Shih-Jen; Shen, Cheng-Che
• Other Names: J nsson Erik Academic Editor.
• Is Part Of: Case reports in psychiatry. Volume 2022(2022)
• Publication Date: 2022-05-16
• Subjects: Psychiatry -- Periodicals; Psychiatry -- Case studies -- Periodicals; Mental Disorders; Psychiatry; Psychiatry; Periodicals; Case studies; Periodicals; 616.89
• DOI: 10.1155/2022/8732708
• Languages: English
• ISSNs: 2090-682X

Abstract

Abstract : Amisulpride is an atypical antipsychotic. It is also effective in treating depression. The potential antidepressant effect raises the concern that amisulpride can induce mania. However, reports of amisulpride-induced mania have been rare. Here, we present the case of a Taiwanese woman with a 22-year history of schizophrenia. At the age 57 years, she developed manic symptoms while on treatment with amisulpride for six weeks. She was immediately admitted to the psychiatric in-patient unit. The manic symptoms completely subsided within eight days without the administration of any mood stabilizer. Readministration of a single dose of 200 mg amisulpride during hospitalization induced the same manic symptoms, which remitted completely within 24 hours without any mood stabilizer administration.